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Profile - Anh-Khoi Nguyen
Anh-Khoi Nguyen
Contact Information
E-mail: agnguyen@usc.edu
Phone: (858) 775-7141
Mail Code: 0371
Started at USC: Fall 2008
Education:
2008 – present
Graduate Student, Integrative & Evolutionary Biology
University of Southern California, Los Angeles
1996 ��� 2001
B.S.,�� Microbiology
B.A.,�� Music Composition
University of California, San Diego, San Diego
Faculty Advisor(s):
Dr. Casey Donovan, Kinesiology
Collaboration(s):
Dr. Alan Watts, Neurobiology
Research Abstract:
Glucose homeostasis is a conserved evolutionary state that is critical to the normal physiological functions of humans and many animal species.�� Different sensory neurons belonging to the central nervous system (CNS) and peripheral vasculature are actively monitoring the fluctuations in plasma glucose.�� In type 1 and advanced type 2 diabetes, hypoglycemia elicits a glucose counterregulation that is characterized by the activation of the sympathoadrenal response ��� secretion of catecholamines.�� Our lab has been investigating the role of afferent sensors located in the hepatic portal veins and their contribution to the hierarchy of glucose counterregulation during hypoglycemic conditions.�� We and others have shown that portal vein afferents are crucial to the modulation of full sympathoadrenal response.�� Presently, I am studying the intricate cross talk between the portal and CNS glucosensors in mice during hypoglycemic states.�� The goal is to further elucidate whole body integration of hypoglycemic detections that is essential to the physiology and functionality of humans and animals.
Recent Publications:
Chung J, Nguyen AK, Henstridge DC, Holmes AG, Chan MH, Mesa JL, Lancaster GI, Southgate RJ, Bruce CR, Duffy SJ, Horvath I, Mestril R, Watt MJ, Hooper PL, Kingwell BA, Vigh L, Hevener A, Febbraio MA.�� HSP72 protects against obesity-induced insulin resistance.�� Proc Natl Acad Sci USA 105:1739-44, 2008.
CV: Click to view