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Profile - Lindsey Bogachus
Lindsey Bogachus
Contact Information
E-mail: bogachus@usc.edu
Phone:
(213) 740-8916
Mail Code: 0371
Started at USC: Fall 2006
Education:
2006 ��� present
Graduate Student, Integrative & Evolutionary Biology
University of Southern California, Los Angeles
2002 ��� 2006
B.S., Food Science
Minor in Business Administration
Washington State University, Pullman
Faculty Advisor(s):
Dr. Lorraine Turcotte, Kinesiology
Research Topics:
L6 myotubes, signaling pathways in long-chain fatty acid metabolism
Research Description:
L6 myotubes are used to examine the effects of exercise on insulin sensitivity. Research on the signaling pathways involved in long chain fatty acid metabolism in muscle; uptake into the cells and oxidation (utilization) within the cells.
Research Abstract:
The current Homo sapien genome was originally selected for when daily physical activity was obligatory for survival. The current discrepancy between energy input (food intake) and energy output (physical activity) has resulted in obesity and a myriad of disorders including insulin resistance and Type II Diabetes. This current obesity epidemic can be directly connected to a decrease in physical activity in our modern day affluent Western society. Since insulin resistance is such a problem today, I am studying the effects of insulin resistance on both fatty acid and glucose metabolism. My line of research is conducted on the L6 skeletal muscle cell line and will also integrate the effects of simulated exercise through the administration of pharmacological agents since exercise has been shown to increase skeletal muscle insulin sensitivity. I not only measure glucose and fatty acid kinetics, but also the exercise- and insulin-induced intracellular signaling pathways. Through my research, insulin resistance on a molecular level can be further understood. We are also interacting with other labs to measure the extent of metabolic dysregulation when specific signaling intermediates are genetically manipulated. These types of studies allow us to make conclusions about the convergence of signaling cascades in the regulation of metabolic homeostasis and of growth and development.
Undergraduate Volunteers:
Every semester, I supervise 1-2 undergraduate research assistants who have received funding from either the Rose Hills or Provost Research Fellowship Program to help with our studies in the laboratory.
CV: Click to view