Faculty
Biological Sciences has more than 60 full-time faculty members, as well as more than 20 faculty with joint appointments and 15 visiting or adjunct professors. Among its many distinctions and honors, the Ph.D. program faculty includes two members of the National Academy of Sciences, four members of the American Academy of Arts and Sciences, and 18 holders of endowed chairs and professorships.
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Peter CalabreseAssistant Professor (research) of Biological SciencesContact Information E-mail: petercal@hto.usc.edu Phone: (213) 740-2434 Office: RRI 413G LINKS Curriculum Vitae Personal Website |
Biographical Sketch
Peter Calabrese received his undergraduate degree in mathematics from the University of Maryland, College Park; his Ph.D. in applied mathematics from Cornell University (Rick Durrett thesis advisor); and was a National Science Foundation mathematics post-doctoral fellow at the University of Southern California (Simon Tavaré sponsoring scientist). His research is in the field of computational biology, and he has collaborated with numerous molecular biology laboratories at USC.
Education
- Ph.D. Applied Mathematics, Cornell University, 2001
Postdoctoral Training
- NSF Math Post-doctoral Fellow, University of Southern California, 2001-2003
Description of Research
Summary Statement of Research Interests
I am interested in applying probability to problems in biology. I have worked on mathematical modeling both in terms of population genetics and stem cell dynamics. I have developed innovative computational approaches for inference from these complicated models. Perhaps more than most other computational biologists, I like to closely collaborate with biologists in terms of designing and analyzing experiments. I have also been involved with analyzing large genomic datasets. At USC, I have collaborated with the laboratories of Norman Arnheim, Magnus Nordborg, Myron Goodman, Sergey Nuzhdin, Paul Marjoram, and Darryl Shibata.
Research Keywords
Computational biology,
Population genetics,
Mutation mechanisms,
Recombination hot spots,
Approximate Bayesian Computation
Publications
Journal Article
- Yoon, S. R., Qin, J., Glaser, R. L., Wang Jabs, E., Wexler, N. S., Sokol, R., Arnheim, N., Calabrese, P. P. (2009). The ups and downs of mutation frequencies during aging can account for the apert syndrome paternal age effect. PLoS Genet. Vol. 5 (7), pp. e1000558.
- Arnheim, N., Calabrese, P. P. (2009). Understanding what determines the frequency and pattern of human germline mutations. Nat Rev Genet. Vol. 10 (7), pp. 478-88.
- Choi, S. K., Yoon, S. R., Calabrese, P. P., Arnheim, N. (2008). A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations. Proc Natl Acad Sci U S A. Vol. 105 (29), pp. 10143-8.
- Qin, J., Calabrese, P. P., Tiemann-Boege, I., Shinde, D. N., Yoon, S. R., Gelfand, D., Bauer, K., Arnheim, N. (2007). The molecular anatomy of spontaneous germline mutations in human testes. PLoS Biol. Vol. 5 (9), pp. e224.
- Calabrese, P. P. (2007). A population genetics model with recombination hotspots that are heterogeneous across the population. Proc Natl Acad Sci U S A. Vol. 104 (11), pp. 4748-52.
- Arnheim, N., Calabrese, P. P., Tiemann-Boege, I. (2007). Mammalian meiotic recombination hot spots. Annu Rev Genet. Vol. 41, pp. 369-99.
- Tiemann-Boege, I., Calabrese, P. P., Cochran, D. M., Sokol, R., Arnheim, N. (2006). High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing. PLoS Genet. Vol. 2 (5), pp. e70.
- Calabrese, P. P., Chakravarty, S., Vision, T. J. (2003). Fast identification and statistical evaluation of segmental homologies in comparative maps. Bioinformatics. Vol. 19 Suppl 1, pp. i74-80.
- Arnheim, N., Calabrese, P. P., Nordborg, M. (2003). Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved. Am J Hum Genet. Vol. 73 (1), pp. 5-16.