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Donald Arnold
Associate Professor of Biological Sciences
Contact Information
Office: RRI 204B
Phone: (213)821-1266
E-mail:
darnold@usc.edu
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Biographical Sketch
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Education
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 B.A. , University of Toronto, 1/1986
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Ph.D. , Johns Hopkins University, 9/1992
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Academic Appointment, Affiliation, and Employment History
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Post-Doctoral Fellow, Harvard University, 03/01/1997-09/30/1999
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Post-Doctoral Fellow, Rockefeller University, 09/01/1992-02/28/1997
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Description of Research
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Summary Statement of Research Interests
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Professor Arnold studies how ion channels are targeted to specific subcellular locations in neurons and how electrical activity can modulate that targeting. The physiological properties of a neuron are dependent not only on the properties of ion channels that they expresse, but also on their spatial distributions within that neuron. Little is known about how neurons maintain unique and often complex subcellular patterns of expression for each ion channel.
Arnold uses biolistic transfection, confocal microscopy, cellular and molecular biology methods in his work on ion channels in neuron's synapse, axon and dendrite.
His lab seeks to answer the following questions: What are the specific protein motifs on an ion channel that specify localization at the axon vs. the dendrite, or at sites that are postsynaptic to one input but not to another? How does electrical stimulation of a specific synapse affect ion channel expression at that synapse? What are the molecular motors that mediate transport of ion channels?
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Research Specialties
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Neurobiology
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Publications
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Journal Article
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Arnold, D. B., Rivera, J., Chu, P.
(2007).
The role of Kif5B in Axonal Localization of Kv1 K(+) channels. Europian Journal of Neuroscience. pp. 136-146.
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Chu, P., Rivera, J., Arnold, D. B.
(2006).
A role for Kif17 in transport of Kv4.2. Journal of Biological Chemistry.
Vol. 281, pp. 365-373.
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Rivera, J., Chu, P., Arnold, D. B.
(2005).
The T1 domain of Kv1.3 mediates intracellular targeting to axons. European Journal of Neuroscience/Blackwell.
Vol. (22), pp. p. 1853-62.
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Arnold, D. B.
(2003).
Rivera, J. F., Ahmad, S., Quick, M. W., Liman, E. R., and Arnold, D. B. Nature Neuroscience.
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Arnold, D. B.
(1999).
Arnold DB, Clapham DE Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. Neuron 23(1):149-57 (1999). Neuron.
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Honors and Awards
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Career Development Award, 2004
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NIH/NSF Career Development Award, Independent Scientist Award, National Institute of Mental Health, 2004
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