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Michel Baudry
Professor of Biological Sciences and Biomedical Engineering
Contact Information
Office: HNB 534
Phone: (213)740-9188
E-mail:
baudry@usc.edu
LINKS
Personal Website
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Education
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 B.S. , Lycee Lalande, France, 1/1968
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M.S. Chemistry, Ecole Polytechnique, Paris, France, 1971
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Ph.D. Biochemistry, University of Paris, France, 1/1977
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Description of Research
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Summary Statement of Research Interests
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Professor Baudry researches learning and memory in the brain and is involved with several collaborative projects including the Human Brain Project and a biomedical engineering project exploring the neural tissue/silicon chip interface. He studies the following points of investigation: Mechanisms implicated in long-term synaptic potentiation (LTP) and depression (LTD) in hippocampus and other brain regions; regulation of glutamate receptors; role of oxygen free radicals in neurodenerative diseases and the central nervous system; and mechanisms underlying selective neuronal degeneration.
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Detailed Statement of Research Interests
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RESEARCH INTERESTS:
1. Mechanisms implicated in long-term synaptic potentiation and depression in hippocampus and other brain regions. My laboratory has been investigating for several years the molecular and cellular mechanisms underlying LTP and LTD phenomena in adult rats and rabbits. We have been using a combination of electrophysiological, neurochemical, and neuroanatomical techniques to study the roles of various biochemical processes in regulating short-term as well as long-term changes in synaptic efficacy.
2. Regulation of glutamate receptors. My laboratory has been studying post-translational mechanisms regulating the properties of the AMPA and NMDA receptors. In particular, we are investigating the mechanisms involved in the maturation, processing, insertion and internalization of the receptors. We are also evaluating the role of calpain-mediated truncation of the C-terminal domains of certain subunits of the receptors in receptor function and regulation.
3. Role of oxygen free radicals in central nervous system. As a result of my association with Eukarion, Inc., a small start-up pharmaceutical company in Bedford, MA, my laboratory has been investigating the roles of oxygen free radicals in neurodegenerative phenomena. In particular, we have tested the protective effects of a new class of synthetic catalytic scavengers of reactive oxygen intermediates on neuronal damage elicited by excitotoxins, neurotoxins, and beta-amyloid peptides.
4. Mechanisms underlying selective neuronal degeneration. My laboratory is interested in studying the role of calcium-dependent proteases, calpains, in neuronal degeneration resulting from neuronal insults or injury. Using a combination of pharmacology and mutant mice expressing deletion of calpain genes or mutation of the gene for the endogenous calpain inhibitor, calpastatin, we are evaluating their contribution to neuronal death in various models of neurodegeneration, including models of ischemia and Parkinson's disease.
Additional projects. My laboratory is also involved in several program projects:
* Estrogen and Alzheimer's disease: under this program project, my laboratory is investigating the mechanisms underlying the potential neuroprotective of estrogen and related steroids in Alzheimer's disease.
* Neural tissue/silicon chips interfaces: in collaboration with Dr. Ted Berger, my laboratory is evaluating new technologies to record/stimulate neuronal activity of large ensemble of neurons.
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Affiliations with Research Centers, Labs, and Other Institutions
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Human Brain Project,http://www-hbp.usc.edu/
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Publications
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Book
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Baudry, M., Davis, J. L., Thompson, R. F.
(2000).
Advances in Synaptic Plasticity. Advances in Synaptic Plasticity./The MIT Press.
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Journal Article
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Bi, R., Foy, M., Vouimba, R., Thompson, R. F., Baudry, M.
(2001).
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Proc. Natl. Acad. Sci. USA.
Vol. vol. 98, pp. pp. 13391-13395.
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Bi, R., Broutman, G., Foy, M., Thompson, R. F., Baudry, M.
(2000).
The tyrosine kinase and MAP kinase pathways mediate multiple effects of estrogen in hippocampus. Proc. Natl. Acad. Sci. USA.
Vol. vol. 97, pp. pp. 3602-3607.
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Vouimba, R., Garcia, R., Baudry, M., Thompson, R. F.
(2000).
Potentiation of conditioned freezing following dorsomedial prefrontal cortex lesions does not interfere with fear reduction in mice. Behavioral Neuroscience/Not Available.
Vol. vol. 114, pp. pp. 720-724.
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Garcia, R., Vouimba, R., Baudry, M., Thompson, R. F.
(1999).
The amygdala modulates prefrontal cortex activity relative to conditioned fear. Nature.
Vol. vol. 402, pp. pp. 294-296.
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Hauge, S. A., Tracy, J. A., Baudry, M., Thompson, R. F.
(1998).
Selective changes in AMPA receptors in rabbit cerebellum following classical conditioning of the eyelid-nictitating membrane response. Brain Research.
Vol. vol. 803, pp. pp. 9-18.
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Service to the Profession
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Editorships and Editorial Boards
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Advisory Board Member, Brain Research, 2006-2007
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Advisory Board Member, Neurobiology of Learning and Memory, 2006-2007
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Professional Memberships
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International Society of Neurochemistry, 2006-2007
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Society for Neuroscience, 2006-2007
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