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Education
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 A.B. English and Molecular Biology, University of California, Berkeley, 6/1984
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Ph.D. Biology (genetics), Massachusetts Institute of Technology, 5/1989
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Postdoctoral Training
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Postdoctoral Fellow, Imperial Cancer Research Fund/Oxford University, 08/01/1989-08/01/1993
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Academic Appointment, Affiliation, and Employment History
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Tenure Track Appointments
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Professor, University of Southern California, 2006-
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Associate Professor, University of Southern California, 2004-2006
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Associate Professor, Molecular & Cell Biology Laboratory, The Salk Institute for Biological Studies, 05/01/2000-05/31/2004
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Adjunct Associate Professor, Biology, University of California, San Diego, 05/01/2000-05/31/2004
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Adjunct Assistant Professor, Biology, University of California, San Diego, 01/01/1997-05/01/2000
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Assistant Professor, Molecular Biology & Virology Laboratory, The Salk Institute for Biological Studies, 09/01/1993-05/01/2000
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Visiting and Temporary Appointments
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Visiting Professor in Genetics, University of Copenhagen, Denmark, 06/01/1995-08/01/1995
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Description of Research
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Summary Statement of Research Interests
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Professor Forsburg studies how chromosomes are duplicated and
segregated, using fission yeast as a model genetic system. Using
genetics, molecular biology, and cell biology techniques, her lab
investigates how the proteins required for initiation of DNA
replication, particularly the MCM helicase, contribute to chromosome
structure and genome stability. The Forsburg group has carried out a
detailed in vivo analysis of MCM function in fission yeast. Recent
work has shown that the MCM kinase, Hsk1(Cdc7), is required for proper
function of the heterochromatin at the centromere. Ongoing studies
address the role of recombination and repair proteins in maintaining
genome structure during S phase, particularly during meiosis, and the
interaction between the MCM helicase and chromatin modifying proteins.
The lab increasingly employs advanced imaging methods to complement
their classical genetics, including observation of proteins on
chromosome spreads and imaging of chromatin fibers.
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Research Specialties
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Cancer Biology, DNA replication
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Affiliations with Research Centers, Labs, and Other Institutions
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USC/Norris Cancer Center, member
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Publications
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Journal Article
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Tabancay, A. P., Forsburg, S. L.
(2006).
Eukaryotic DNA replication in a chromatin context. Curr Top Dev Biol.
Vol. 76, pp. 129-84.
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Freeman-Cook, L. L., Gómez, E. G., Spedale, E. J., Marlett, J., Pillus, L., Forsburg, S. L., Laurenson, P.
(2005).
Conserved locus-specific silencing functions of S. pombe sir2+. Genetics.
Vol. 169, pp. 1243-1260.
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Gómez, E. B., Angeles, V. T., Forsburg, S. L.
(2005).
A screen for S. pombe mutants defective in re-replication identifies new alleles of rad4+, cut9+ and psf2+. Genetics. pp. 77-89.
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Gómez, E. B., Espinosa, J., Forsburg, S. L.
(2005).
S. pombe mst2+ encodes a MYST-family histone acetyltransferase required for telomere silencing. Mol. Cell. Biol..
Vol. 25, pp. 8887-8903.
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Huang, H. K., Bailis, J. M., Leverson, J. D., Gomez, E. B., Forsburg, S. L., Hunter, T.
(2005).
Suppressors of Bir1p (Survivin) identify roles for the chromosomal passenger protein Pic1p (INCENP) and the replication initiation factor Psf2p in chromosome segregation. Mol. Cell. Biol..
Vol. 25, pp. 9000-9015.
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Pankratz, D. G., Forsburg, S. L.
(2005).
Meiotic S-phase damage activates recombination without checkpoint arrest. Mol. Biol. Cell.
Vol. 16, pp. 1651-1660.
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Forsburg, S. L.
(2004).
Eukaryotic MCM proteins: beyond replication initiation. Microbiol. Mol. Biol. Rev..
Vol. 68, pp. 109-131.
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Bailis, J. M., Bernard, P., Antonelli, R., Allshire, R., Forsburg, S. L.
(2003).
Hsk1/Dfp1 is required for heterochromatin-mediated cohesion at centromeres. Nat. Cell Biol.. pp. 1111-1116.
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Wood, V., Gwilliam, R., Rajandream, M., Lyne, M., Lyne, R., Stewart, A., Sgouros, J., Peat, N., Hayles, J., Baker, S., Basham, D., Bowman, S., Brooks, K., Brown, D., Brown, S., Fraser, T., Gentles, S., Goble, A., Hamlin, N., Harris, D., Hidalgo, J., Hodgson, G., Holroyd, S., Holroyd, S., Hornsby, T., Howarth, S., Huckle, E. J., Hunt, S., Jagels, K., James, K., Jones, L., Jones, M., Leather, S., Mcdonald, S., McLean, J., Moule, S., Mungail, K., Murphy, L., Niblett, D., Odell, C., Oliver, K., O'Neil, S., Pearson, D., Quail, M. A., Rabbinowitsch, E., Rutherford, K., Rutter, S., Saunders, D., Seeger, K., Sharp, S., skelton, J., Simmonds, M., Squares, R., Squares, s., Stevens, K., Taylor, K., Taylor, R. g., Walsh, S., Warren, T., Whitehead, S., Woodwrd, j., Volckaerv, G., Aert, R., Robben, J., Grymonprez, B., Weltjens, I., Vanstreels, E., Rieger, M., Schofer, M., Muller-Auer, S., Gabel, C., fuchs, M., Fritze, C., Holzer, E., Moestl, D., Hilbert, H., Borzym, K., Langer, I., Beck, A., Lehrach, H., Reinhardt, R., Pohl, T. M., Eger, P., Zimmermann, W., Wedler, H., Wambutt, r., Purnelle, B., Goffeau, A., Cadieu, E., Driano, S., Gloux, S., Lelaure, V., Mottier, S., Galibert, F., Aves, S. J., Xiang, Z., Hunt, C., Moore, K., Hurst, S. M., Lucas, M., Rochet, M., Gaillardin, C., Tailada, V. A., Garzon, A., Thode, G., Daga, R. r., Cruza, L. |.
(2002).
The genome sequence of the eukaryote fission yeast Schizosaccharomyces pombe. Nature.
Vol. 415, pp. 871-880.
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Forsburg, S. L.
(2001).
The art and design of genetic screens: yeast. Nature Rev. Genet..
Vol. 2, pp. 659-668.
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Forsburg, S. L., Hodson, J. A.
(2000).
Mitotic replication initiation proteins are not required for S. pombe pre-meiotic S phase. Nat. Genet..
Vol. 25, pp. 263-268.
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Multimedia Scholarship and Creative Works
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Web Page, Remembering Marguerite Vogt: a biography (web site)
http://www-rcf.usc.edu/~forsburg/vogt.html, 2007-
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Honors and Awards
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Fellow, Association of Women in Science, 2006-2007
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Mellon Mentoring Award Certificate, USC, 2005-2006
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Fellow (or Equivalent) of National Society in Discipline, Fellow, American Association for the Advancement of Science, 2004
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Recipient of National or International Prize in Discipline, Stohlman Scholar, Leukemia & Lymphoma Society, 2002
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Recipient of National or International Prize in Discipline, American Society for Cell Biology WICB Junior Career Recognition Award, 1996
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Service to the Profession
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Professional Memberships
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American Association for the Advancement of Science, 2006-2007
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American Society for Biochemistry and Molecular Biology, 2006-2007
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American Society for Cell Biology, 2006-2007
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Association for Women in Science, 2006-2007
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Genetics Society of America, 2006-2007
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