|
Education
|
 B.S. Chemistry, Aristotle University of Thessaloniki, Greece, 1978
|
|
Ph.D. Organic Chemistry, University of Pennsylvania, 1983
|
| |
Postdoctoral Training
|
|
Research Associate and Adjunct Lecturer, University of Pennsylvania, 1984-1987
|
| |
Description of Research
|
Summary Statement of Research Interests
|
|
Organic Chemistry and Medicinal Chemistry
• New organic reactions: New reactions of organotitanium, organoaluminum and organoboron compounds. New methods for asymmetric synthesis and catalysis.
• New technologies: New processes for hydrocarbon and energy-related chemistry. New technologies for process chemistry. New advanced materials.
• New strategies: New concepts for the synthesis of amines, amino acids, amino alcohols, amino sugars, peptidomimetics and heterocycles. New strategies for combinatorial chemistry, medicinal chemistry and drug discovery.
• New bioactive molecules: New bioactive heterocycles. New polyunsaturated lipid mediators including lipoxins, resolvins, protectins. New metabolites of omega-3 fatty acids.
• New therapies: Design, synthesis and study of new therapeutic and chemo-preventive agents. Development of new methods for the treatment of inflammation, periodontal disease, cystic fibrosis, neurodegenerative diseases, and cancer.
|
| |
Affiliations with Research Centers, Labs, and Other Institutions
|
|
Loker Hydrocarbon Research Institute
|
|
USC/Norris Comprehensive Cancer Center
|
| |
Publications
|
Journal Article
|
|
Petasis, N. A., Keledjian, R., Sun, Y., Nagulapalli, K. C., Tjonahen, E., Yang, R., Serhan, C. N.
(2008).
Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties. Bioorganic & Medicinal Chemistry Letters.
Vol. 18 (4), pp. 1382–1387.
|
|
Schonthal, A. H., Chen, T. C., Hofman, F. M., Louie, S. G., Petasis, N. A.
(2008).
Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. Expert Opinion on Investigational Drugs.
Vol. 17 (2), pp. 197-208.
|
|
Petasis, N. A.
(2007).
Expanding roles for organoboron compounds - Versatile and valuable molecules for synthetic, biological, and medicinal chemistry. Australian Journal of Chemistry.
Vol. 60 (11), pp. 795-798.
|
|
Pyrko, P., Kardosh, A., Liu, Y. T., Soriano, N., Xiong, W. Y., Chow, R. H., Uddin, J., Petasis, N. A., Mircheff, A. K., Farley, R. A., Louie, S. G., Chen, T. C., Schothal, A. H.
(2007).
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Molecular Cancer Therapeutics.
Vol. 6 (4), pp. 1262-1275.
|
|
Sun, Y. P., Oh, S. F., Uddin, J., Yang, R., Gotlinger, K., Campbell, E., Colgan, S. P., Petasis, N. A., Serhan, C. N.
(2007).
Resolvin D1 and its aspirin-triggered 17R epimer - Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. Journal of Biological Chemistry.
Vol. 282 (13), pp. 9323-9334.
|
|
Arita, M., Oh, S. F., Chonan, T., Hong, S., Elangovan, S., Sun, Y. P., Uddin, J., Petasis, N. A., Serhan, C. N.
(2006).
Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. Journal of Biological Chemistry.
Vol. 281 (32), pp. 22847-22854.
|
|
Bonnans, C., Fukunaga, K., Keledjian, R., Petasis, N. A., Levy, B. D.
(2006).
Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury. Journal of Experimental Medicine.
Vol. 203 (4), pp. 857-863.
|
|
Pyrko, P., Soriano, N., Kardosh, A., Liu, Y. T., Uddin, J., Petasis, N. A., Hofman, F. M., Chen, C. S., Chen, T. C., Schonthal, A. H.
(2006).
Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. Molecular Cancer.
Vol. 5 (19), pp. 1-16.
|
|
Serhan, C. N., Gotlinger, K., Hong, S., Lu, Y., Siegelman, J., Baer, T., Yang, R., Colgan, S. P., Petasis, N. A.
(2006).
Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienes. Journal of Immunology.
Vol. 176 (3), pp. 1848-1859.
|
|
Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., Serhan, C. N.
(2005).
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. Journal of Experimental Medicine.
Vol. 201 (5), pp. 713-722.
|
|
Karp, C. L., Flick, L. M., Yang, R., Uddin, J., Petasis, N. A.
(2005).
Cystic fibrosis and lipoxins. Prostaglandins Leukotrienes and Essential Fatty Acids.
Vol. 73 (3-4), pp. 263-270.
|
|
Levy, B. D., Hickey, L., Morris, A. J., Larvie, M., Keledjian, R., Petasis, N. A., Bannenberg, G., Serhan, C. N.
(2005).
Novel polyisoprenyl phosphates block phospholipase D and human neutrophil activation in vitro and murine peritoneal inflammation in vivo. British Journal of Pharmacology.
Vol. 146 (3), pp. 344-351.
|
|
Petasis, N. A., Akritopoulou-Zanze, I., Fokin, V. V., Bernasconi, G., Keledjian, R., Yang, R., Uddin, J., Nagulapalli, K. C., Serhan, C. N.
(2005).
Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins. Prostaglandins Leukotrienes and Essential Fatty Acids.
Vol. 73 (3-4), pp. 301-321.
|
|
Karp, C. L., Flick, L. M., Park, K. W., Softic, S., Greer, T. M., Keledjian, R., Yang, R., Uddin, J., Guggino, W. B., Atabani, S. F., Belkaid, Y., Xu, Y., Whitsett, J. A., Accurso, F. J., Wills-Karp, M., Petasis, N. A.
(2004).
Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nature Immunology.
Vol. 5 (4), pp. 388-392.
|
|
Prakash, G. K., Mandal, M., Schweizer, S., Petasis, N. A., Olah, G. A.
(2002).
Stereoselective synthesis of anti-alpha-(difluoromethyl)-beta-amino alcohols by boronic acid based three-component condensation. Stereoselective preparation of (2S,3R)-difluorothreonine. Journal of Organic Chemistry.
Vol. 67 (11), pp. 3718-3723.
|
|
Petasis, N. A., Boral, S.
(2001).
One-step three-component reaction among organoboronic acids, amines and salicylaldehydes. Tetrahedron Letters.
Vol. 42 (4), pp. 539-542.
|
|
Petasis, N. A., Patel, Z. D.
(2000).
Synthesis of piperazinones and benzopiperazinones from 1,2-diamines and organoboronic acids. Tetrahedron Letters.
Vol. 41 (49), pp. 9607-9611.
|
|
Prakash, G. K., Mandal, M., Schweizer, S., Petasis, N. A., Olah, G. A.
(2000).
A facile stereocontrolled synthesis of anti-alpha-(trifluoromethyl)-beta-amino alcohols. Organic Letters.
Vol. 2 (20), pp. 3173-3176.
|
|
You, Y. J., He, Y. K., Borrows, P. E., Forrest, S. R., Petasis, N. A., Thompson, M. E.
(2000).
Fluorophores related to the green fluorescent protein and their use in optoelectronic devices. Advanced Materials.
Vol. 12 (22), pp. 1678-1679.
|
|
Petasis, N. A., Zavialov, I. A.
(1998).
Highly stereocontrolled one-step synthesis of anti-beta-amino alcohols from organoboronic acids, amines, and alpha-hydroxy aldehydes. Journal of the American Chemical Society.
Vol. 120 (45), pp. 11798-11799.
|
|
Levy, B. D., Petasis, N. A., Serhan, C. N.
(1997).
Polyisoprenyl phosphates in intracellular signalling. Nature.
Vol. 389 (6654), pp. 985-990.
|
|
Petasis, N. A., Goodman, A., Zavialov, I. A.
(1997).
A new synthesis of alpha-arylglycines from aryl boronic acids. Tetrahedron.
Vol. 53 (48), pp. 16463-16470.
|
|
Petasis, N. A., Hu, Y. H.
(1997).
Allenation of carbonyl compounds with alkenyltitanocene derivatives. Journal of Organic Chemistry.
Vol. 62 (4), pp. 782-783.
|
|
Petasis, N. A., Zavialov, I. A.
(1997).
A new and practical synthesis of alpha-amino acids from alkenyl boronic acids. Journal of the American Chemical Society.
Vol. 119 (2), pp. 445-446.
|
| |
Honors and Awards
|
|
Endowed Chair, Harold and Lillian Moulton Chair in Chemistry, 2001-
|
|
Novartis Chemistry Lectureship, 2007-2008
|
|
USC Associates Award For Creativity In Research And Scholarship, 2007-2008
|
|
Boron Americas Award for Distinguished Achievements in Boron Science, 2002-2003
|
|
USC Academic Senate Executive Board, Secretary General, 1998-2000
|
| |
Service to the University
|
Administrative Appointments
|
|
Head, Organic/Materials Division, Department of Chemistry, 2005-
|
| |
Committees
|
|
Member, University Committee on Academic Program Review, 2007-
|
|
Member, USC College, Natural Sciences and Mathematics Personnel Committee
, 2005-2007
|
|
Member, University Research Committee, 1998-2000
|
|
Co-Chair, Provost’s Special Committee on Faculty Review, 1998-1999
|
|
Member, Committee on General Education, USC College, 1997-1998
|
| |
Service to the Profession
|
Editorships and Editorial Boards
|
|
Member, Editorial Board, Research Letters in Organic Chemistry, 2007-
|
| |
| |
|
Faculty may update their profile by logging into the College portal from a computer on campus or off-campus via a VPN connection.
|
|
 |
|
