Education
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 Ph.D. , University of Chicago, 1/1962
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Description of Research
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Summary Statement of Research Interests
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Professor Petruska's research interests include DNA methylation, mutagenesis and evolution. His research investigates the mechanisms of mutation "hot" and "cold" spots in relation to evolution. He examines nearest-neighbor influences on point mutations arising through DNA polymerases and DNA methylases. Professor Petruska is currently investigating the consequences of CG replacements by TG or CA and their suppression.
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Publications
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Other
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Petruska, J. A. Hartenstine MJ, Goodman MF, Petruska J. Weak strand displacement activity enables human DNA polymerase beta to expand CAG/CTG triplet repeats at strand breaks. J Biol Chem. 2002. Nov 1;277(44):41379-89.
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Petruska, J. A. Hartenstine MJ, Goodman MF, Petruska J. Base stacking and even/odd behavior of hairpin loops in DNA triplet repeat slippage and expansion with DNA polymerase. J Biol Chem. 2000 Jun 16;275(24):18382-90.
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Petruska, J. A. Petruska J, Arnheim N, Goodman MF. Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. Nucleic Acids Res. [ 1996 ] Jun 1;24(11):1992-8.
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