Casey Donovan Professor of Kinesiology and Biological Sciences Contact Information E-mail: donovan@usc.edu Phone: (213) 740-2492 Office: PED 107 LINKS Curriculum Vitae

 

Education

• B.A. , University of California, Berkeley, 1/1974
• M.A. , University of California, Berkeley, 1/1978
• Ph.D. , University of California, Berkeley, 1/1982

Postdoctoral Training

• NRSA Posdoctoral Fellow, University of Michigan Medical School, 1982-1984  

Academic Appointment, Affiliation, and Employment History

Tenure Track Appointments

• Professor of Integrative and Evolutionary Biology, University of Southern California, 01/01/2003-  
• Professor of Kinesiology, University of Southern California, 01/01/1999-  
• Chair, Kinesiology, University of Southern California, 01/01/1995-01/01/2004  
• Associate Professor, University of Southern California, 01/01/1990-01/01/1999  
• Assistant Professor, University of Southern California, 01/01/1984-01/01/1990  

PostDoctoral Appointments

• NRSA Postdoctoral Fellow, University of Michigan Medical School, 1981-1984  

Description of Research

Summary Statement of Research Interests

Our efforts are directed at understanding the mechanisms by which the body detects low blood sugar (hypoglycemia) and how it integrates that information to generate corrective responses. We are particularly interested in peripheral glucose sensors located in the gut, which play a prominent role in detecting small or slow changes in blood glucose. We have characterized various aspects of these sensory neurons, i.e. type, origin, metabolism, and have begun to exam their role in pathological states, e.g. diabetes. In collaboration with Dr. Alan Watts (Neuroscience) we are also examining the interaction between these peripheral glucose sensors and those located in the brain.

Research Keywords

glucose sensing, hypoglycemia, peripheral afferents, carbohydrate metabolism, diabetes

Publications

Journal Article

• Alan, W. G., Donovan, C. M. (2009). Sweet Talk In The Brain: Glucosensing, Neural Networks, and Hypoglycemic Counterregulation. Front. Neuroendocrinol.. Vol. [Epub ahead of print]
• Donovan, C. M., Bohland, M. (2009). Hypoglycemic detection at the portal vein: Absent in humans or yet to be elucidated?. Diabetes. Vol. 58 (1), pp. 21-23.
• Saberi, M., Bohland, M., Donovan, C. M. (2008). The Locus for Hypoglycemic Detection Shifts with the Rate of Fall in Glycemia: The Role of Portal-Mesenteric Glucose Sensors. Diabetes. Vol. 57, pp. 1380-1386.
• Matveyenko, A. V., Bohland, M., Saberi, M., Donovan, C. M. (2007). Portal vein hypoglycemia is essential for full induction of hypoglycemia-associated autonomic failure with slow-onset hypoglycemia. Am J Physiol: Endocrinol Metab.. Vol. 293 (3), pp. E857-E864.
• Fujita, S., Bohland, M., Sanchez-Watts, G., Watts, A. G., Donovan, C. M. (2007). Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons. American Journal of Physiology: Endocrinology & Metabolism. Vol. 293 (1), pp. E96-E101.
• Gorton, L. M., Khan, A. M., Sanchez-Watts, G., Donovan, C. M., Watts, A. G. (2007). A role for the forebrain in mediating time-of-day differences in glucocorticoids counterregulatory responses to hypoglycemia in rats. Endocrinology.
• Sumida, K., Urdiales, J. H., Donovan, C. (2006). Impact of flow rate on lactate uptake and gluconeogenesis in glucagon-stimulated perfused livers. American Journal of Physiology, Endocrinology & Metabolism/Highwire Press. Vol. 290(1), pp. E185-E191.
• Sumida, K., Urdiales, J. H., Donovan, C. (2006). Lactate delivery (not oxygen) limits hepatic gluconeogenesis when blood flow is reduced. American Journal of Physiology, Endocrinology & Metabolism/Highwire Press. Vol. 290(1), pp. E192-E198.
• Matveyenko, A., Donovan, C. (2006). Metabolic sensors mediate hypoglycemic detection at the portal vein. Diabetes/American Diabetes Association. Vol. 55, pp. 1276-1282.
• Fujita, S., Donovan, C. (2005). Celiac-superior mesenteric ganglionectomy, but not vagotomy, suppresses the sympathoadrenal response to insulin-induced hypoglycemia. Diabetes/American Diabetes Association. Vol. 54(11), pp. 3258-64.

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