Lu Chen received a "genius grant" from the MacArthur Foundation.
Photo courtesy of Lu Chen.
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‘Genius’ of Memory
Alumna Wins MacArthur Award
It’s official. As one of the 2005 winners of the prestigious MacArthur
Foundation Fellowships, USC College alumna Lu Chen (Ph.D.,
Neuroscience, ’98) is a “genius.”
Chen, a neurobiologist at UC Berkeley, said receiving the Fellowship
“was a huge surprise. I never thought it would happen to me.”
When she received an early morning call about the award in September, her first response, she said, was “What?!”
Her former adviser, Richard F. Thompson, was not so surprised. “She is
one of the most outstanding students I have ever had,” said Thompson,
the W.M. Keck Professor of Biological Sciences and Psychology in the
College and a member of the National Academy of Sciences.
The MacArthur Fellowships, commonly referred to as “genius grants,” are
awarded annually to individuals who show exceptional merit and promise
for continued and enhanced creative work. Recipients can use the
five-year, unrestricted $500,000 grants as they wish.
Chen, 33, was one of 25 winners nationwide, including scholars,
artists, writers and others “willing to take risks, transcend and
expand boundaries,” MacArthur program director Dan Socolow told the San
Francisco Chronicle.
Chen earned her B.S. in molecular biology in her native China, but had
always been interested in the brain and memory. “Memory was something
that even a naïve student could relate to their everyday life,” she
said. Accepted into USC’s program, she read about Thompson’s work in
the program brochure. Before arriving on campus, she had set her sights
on working with him.
“Dick is probably the smartest person I’ve ever met in my life,” Chen
said. “I consider myself very lucky to have joined his lab. What I
treasure most was the emphasis on independent thinking.”
Chen’s dissertation research focused on identifying neural pathways in
the cerebellum important in learning, looking at both the genetic and
cellular levels. Using a strain of mutant mice, Chen and Thompson were
the first to show that the cerebellar cortex facilitates learning in
mice and controls the timing of behaviors, she said.
After postdocs at USC and UC San Francisco, Chen joined the Cal faculty
in 2003, where her husband and fellow neuroscientist Shaowen Bao also
works.
Chen has made a number of contributions to the basic biology of
learning and memory. While she continues to study the mutant mice she
worked with at USC, her scientific interests have broadened in recent
years.
She studies synapses, the junctures between nerve cells that transmit
critical signals from one cell to the next, and the role of the
neurotransmitter glutamate at synapses. She has developed a powerful
lab model, called the hybrid cell system, to better study the problem.
“We’re interested in the molecular mechanisms of synaptic formation,
studying the roles of different proteins in the process,” she said. “If
we understand how it works normally, that would provide insight into
what we can do if it doesn’t work,” as in some neurological diseases.
What will Chen do with the $500,000? “I’ll be putting it into savings.”
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